Thiadiazines, N,N-heterocycles of biological relevance.
نویسندگان
چکیده
The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold has found many applications in recent years. This review is aimed at highlighting the most important aspects of these compounds: synthesis, spectroscopic characterization and biological activities. How the chemical nature of N-substituents influences the overall activity and cytotoxicity profile will also be discussed.
منابع مشابه
Three Component Syntheses of Pyrrolo Imidazole Derivatives in the Presence of N-methyl imidazole, Activated Acetylenes and Phenylsulfonylacetophenone
Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic, industry and applied-oriented chemists. Considerably, ascientific renaissance of heterocycles during the last decades is closely related to the development of multicomponent approaches to their s...
متن کاملNovel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.
متن کاملNovel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives.
متن کاملCopper-promoted aerial oxidation of benzothiadiazines: access to benzothiadiazine S-oxide heterocycles.
Cu(II)-promoted aerial oxidation of a series of benzothiadiazines () under ambient conditions affords the first structurally characterised examples of thiadiazine S-oxides (). The isolation of the homoleptic Cu(II) 3-(2'-pyridyl)benzothiadiazide-S-oxide complex provides insight into the reaction mechanism.
متن کاملStudy of the inhibitory effects of N-heterocycles, magnesium oxide nanoparticles, nisin and poly-L-lysine on Enterobacter aerogenes (hospital pathogen)
Background: Enterobacter aerogenesis one of the causes of hospital-acquired infections, which its standard strains quickly become resistant to the antibiotics. The discovery of new inhibitory agents against this pathogen is constantly expanding. In this study, the inhibitory effects of several synthetic chemical compounds including magnesium oxide nanoparticles and thiazole, imidazolidine and t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 17 7 شماره
صفحات -
تاریخ انتشار 2012